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cb 2 cannabinoid receptor antagonist am630  (Tocris)


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    Tocris cb 2 cannabinoid receptor antagonist am630
    Schematic diagram of the experimental protocol. A , Kahweol (Kah) was administered 175 min after the local administration of prostaglandin E 2 (PGE 2 ) (2 µg) and the antinociceptive response was measured prior to and 180 min, 195 min, and 210 min after PGE 2 injection. B , Kah was administered in the right hind paw 175 min after local injection of PGE 2 . The cannabinoid drugs AM251, <t>AM630,</t> MAFP, JZL184, or VDM11 were given 10 min prior (165 min) to Kah intraplantar administration and measurements were performed prior to and 180 min after PGE 2 administration.
    Cb 2 Cannabinoid Receptor Antagonist Am630, supplied by Tocris, used in various techniques. Bioz Stars score: 96/100, based on 610 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/cb+2+cannabinoid+receptor+antagonist+am630/pmc08555452-42-20-31?v=Tocris
    Average 96 stars, based on 610 article reviews
    cb 2 cannabinoid receptor antagonist am630 - by Bioz Stars, 2026-07
    96/100 stars

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    1) Product Images from "Kahweol, a natural diterpene from coffee, induces peripheral antinociception by endocannabinoid system activation"

    Article Title: Kahweol, a natural diterpene from coffee, induces peripheral antinociception by endocannabinoid system activation

    Journal: Brazilian Journal of Medical and Biological Research

    doi: 10.1590/1414-431X2021e11071

    Schematic diagram of the experimental protocol. A , Kahweol (Kah) was administered 175 min after the local administration of prostaglandin E 2 (PGE 2 ) (2 µg) and the antinociceptive response was measured prior to and 180 min, 195 min, and 210 min after PGE 2 injection. B , Kah was administered in the right hind paw 175 min after local injection of PGE 2 . The cannabinoid drugs AM251, AM630, MAFP, JZL184, or VDM11 were given 10 min prior (165 min) to Kah intraplantar administration and measurements were performed prior to and 180 min after PGE 2 administration.
    Figure Legend Snippet: Schematic diagram of the experimental protocol. A , Kahweol (Kah) was administered 175 min after the local administration of prostaglandin E 2 (PGE 2 ) (2 µg) and the antinociceptive response was measured prior to and 180 min, 195 min, and 210 min after PGE 2 injection. B , Kah was administered in the right hind paw 175 min after local injection of PGE 2 . The cannabinoid drugs AM251, AM630, MAFP, JZL184, or VDM11 were given 10 min prior (165 min) to Kah intraplantar administration and measurements were performed prior to and 180 min after PGE 2 administration.

    Techniques Used: Injection

    The CB 2 receptor antagonist did not block kahweol-induced peripheral antinociception in hyperalgesic paws. The antinociceptive response was measured by the paw pressure test. Prostaglandin E 2 (PGE 2 ) injection (2 µg/paw) was done at time 0, AM630 (100 µg/paw) was injected at time 165 min, and kahweol (Kah; 80 µg/paw) was given at 175 min. Measurements were made prior to and 180 min after PGE 2 administration. Data are reported as means±SE (n=5) of Δ nociceptive threshold measured in grams (g). *P<0.05 compared to PGE 2 + Veh 2 + Veh 3-injected group (ANOVA and Bonferroni's test). There was no significant difference between (PGE 2 + Veh 2 + Kah 80) and (PGE 2 + AM630 100 + Kah 80)-injected groups. Veh (vehicle) 2: 10% DMSO in saline; Veh 3: sterile saline solution (0.9% NaCl).
    Figure Legend Snippet: The CB 2 receptor antagonist did not block kahweol-induced peripheral antinociception in hyperalgesic paws. The antinociceptive response was measured by the paw pressure test. Prostaglandin E 2 (PGE 2 ) injection (2 µg/paw) was done at time 0, AM630 (100 µg/paw) was injected at time 165 min, and kahweol (Kah; 80 µg/paw) was given at 175 min. Measurements were made prior to and 180 min after PGE 2 administration. Data are reported as means±SE (n=5) of Δ nociceptive threshold measured in grams (g). *P<0.05 compared to PGE 2 + Veh 2 + Veh 3-injected group (ANOVA and Bonferroni's test). There was no significant difference between (PGE 2 + Veh 2 + Kah 80) and (PGE 2 + AM630 100 + Kah 80)-injected groups. Veh (vehicle) 2: 10% DMSO in saline; Veh 3: sterile saline solution (0.9% NaCl).

    Techniques Used: Blocking Assay, Randall–Selitto Test, Injection, Saline, Sterility



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    cb 2 cannabinoid receptor antagonist am630  (Tocris)
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    Schematic diagram of the experimental protocol. A , Kahweol (Kah) was administered 175 min after the local administration of prostaglandin E 2 (PGE 2 ) (2 µg) and the antinociceptive response was measured prior to and 180 min, 195 min, and 210 min after PGE 2 injection. B , Kah was administered in the right hind paw 175 min after local injection of PGE 2 . The cannabinoid drugs AM251, <t>AM630,</t> MAFP, JZL184, or VDM11 were given 10 min prior (165 min) to Kah intraplantar administration and measurements were performed prior to and 180 min after PGE 2 administration.
    Cb 2 Cannabinoid Receptor Antagonist Am630, supplied by Tocris, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/cb+2+cannabinoid+receptor+antagonist+am630/pmc08555452-42-20-31?v=Tocris
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    cannabinoid cb 2 receptor antagonist/inverse agonist am630  (Tocris)
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    Schematic diagram of the experimental protocol. A , Kahweol (Kah) was administered 175 min after the local administration of prostaglandin E 2 (PGE 2 ) (2 µg) and the antinociceptive response was measured prior to and 180 min, 195 min, and 210 min after PGE 2 injection. B , Kah was administered in the right hind paw 175 min after local injection of PGE 2 . The cannabinoid drugs AM251, <t>AM630,</t> MAFP, JZL184, or VDM11 were given 10 min prior (165 min) to Kah intraplantar administration and measurements were performed prior to and 180 min after PGE 2 administration.
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    cannabinoid cb 2 receptor antagonist am630  (Tocris)
    96
    Tocris cannabinoid cb 2 receptor antagonist am630
    Schematic diagram of the experimental protocol. A , Kahweol (Kah) was administered 175 min after the local administration of prostaglandin E 2 (PGE 2 ) (2 µg) and the antinociceptive response was measured prior to and 180 min, 195 min, and 210 min after PGE 2 injection. B , Kah was administered in the right hind paw 175 min after local injection of PGE 2 . The cannabinoid drugs AM251, <t>AM630,</t> MAFP, JZL184, or VDM11 were given 10 min prior (165 min) to Kah intraplantar administration and measurements were performed prior to and 180 min after PGE 2 administration.
    Cannabinoid Cb 2 Receptor Antagonist Am630, supplied by Tocris, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/cb+2+cannabinoid+receptor+antagonist+am630/pmc03035076-101-1-17?v=Tocris
    Average 96 stars, based on 1 article reviews
    cannabinoid cb 2 receptor antagonist am630 - by Bioz Stars, 2026-07
    96/100 stars
    		  Buy from Supplier

    Image Search Results


    Schematic diagram of the experimental protocol. A , Kahweol (Kah) was administered 175 min after the local administration of prostaglandin E 2 (PGE 2 ) (2 µg) and the antinociceptive response was measured prior to and 180 min, 195 min, and 210 min after PGE 2 injection. B , Kah was administered in the right hind paw 175 min after local injection of PGE 2 . The cannabinoid drugs AM251, AM630, MAFP, JZL184, or VDM11 were given 10 min prior (165 min) to Kah intraplantar administration and measurements were performed prior to and 180 min after PGE 2 administration.

    Journal: Brazilian Journal of Medical and Biological Research

    Article Title: Kahweol, a natural diterpene from coffee, induces peripheral antinociception by endocannabinoid system activation

    doi: 10.1590/1414-431X2021e11071

    Figure Lengend Snippet: Schematic diagram of the experimental protocol. A , Kahweol (Kah) was administered 175 min after the local administration of prostaglandin E 2 (PGE 2 ) (2 µg) and the antinociceptive response was measured prior to and 180 min, 195 min, and 210 min after PGE 2 injection. B , Kah was administered in the right hind paw 175 min after local injection of PGE 2 . The cannabinoid drugs AM251, AM630, MAFP, JZL184, or VDM11 were given 10 min prior (165 min) to Kah intraplantar administration and measurements were performed prior to and 180 min after PGE 2 administration.

    Article Snippet: The CB 1 cannabinoid receptor antagonist AM251 ( N -[piperidin-1-yl]-5-[4-iodophenyl]-1-[2,4-dichlorophenyl]-4-methyl-1 H -pyrazole-3-carboxamide; purity>99%; Tocris) (20, 40, 80 μg/paw) and the CB 2 cannabinoid receptor antagonist AM630 (6-Iodo-2-methyl-1-[2-{4-morpholinyl}ethyl]-1H-indol-3-yl [4-ethoxyphenyl] methanone; purity >98%; Tocris) (100 μg/paw) were dissolved in 10% DMSO, whereas the hyperalgesic agent PGE 2 (purity ≥93%; Sigma-Aldrich, USA) was dissolved in 2% ethanol.

    Techniques: Injection

    The CB 2 receptor antagonist did not block kahweol-induced peripheral antinociception in hyperalgesic paws. The antinociceptive response was measured by the paw pressure test. Prostaglandin E 2 (PGE 2 ) injection (2 µg/paw) was done at time 0, AM630 (100 µg/paw) was injected at time 165 min, and kahweol (Kah; 80 µg/paw) was given at 175 min. Measurements were made prior to and 180 min after PGE 2 administration. Data are reported as means±SE (n=5) of Δ nociceptive threshold measured in grams (g). *P<0.05 compared to PGE 2 + Veh 2 + Veh 3-injected group (ANOVA and Bonferroni's test). There was no significant difference between (PGE 2 + Veh 2 + Kah 80) and (PGE 2 + AM630 100 + Kah 80)-injected groups. Veh (vehicle) 2: 10% DMSO in saline; Veh 3: sterile saline solution (0.9% NaCl).

    Journal: Brazilian Journal of Medical and Biological Research

    Article Title: Kahweol, a natural diterpene from coffee, induces peripheral antinociception by endocannabinoid system activation

    doi: 10.1590/1414-431X2021e11071

    Figure Lengend Snippet: The CB 2 receptor antagonist did not block kahweol-induced peripheral antinociception in hyperalgesic paws. The antinociceptive response was measured by the paw pressure test. Prostaglandin E 2 (PGE 2 ) injection (2 µg/paw) was done at time 0, AM630 (100 µg/paw) was injected at time 165 min, and kahweol (Kah; 80 µg/paw) was given at 175 min. Measurements were made prior to and 180 min after PGE 2 administration. Data are reported as means±SE (n=5) of Δ nociceptive threshold measured in grams (g). *P<0.05 compared to PGE 2 + Veh 2 + Veh 3-injected group (ANOVA and Bonferroni's test). There was no significant difference between (PGE 2 + Veh 2 + Kah 80) and (PGE 2 + AM630 100 + Kah 80)-injected groups. Veh (vehicle) 2: 10% DMSO in saline; Veh 3: sterile saline solution (0.9% NaCl).

    Article Snippet: The CB 1 cannabinoid receptor antagonist AM251 ( N -[piperidin-1-yl]-5-[4-iodophenyl]-1-[2,4-dichlorophenyl]-4-methyl-1 H -pyrazole-3-carboxamide; purity>99%; Tocris) (20, 40, 80 μg/paw) and the CB 2 cannabinoid receptor antagonist AM630 (6-Iodo-2-methyl-1-[2-{4-morpholinyl}ethyl]-1H-indol-3-yl [4-ethoxyphenyl] methanone; purity >98%; Tocris) (100 μg/paw) were dissolved in 10% DMSO, whereas the hyperalgesic agent PGE 2 (purity ≥93%; Sigma-Aldrich, USA) was dissolved in 2% ethanol.

    Techniques: Blocking Assay, Randall–Selitto Test, Injection, Saline, Sterility